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Pharmacology

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PMCOL201 Introductory Pharmacology Course Page

Description: An introduction to the discipline of pharmacology. What are drugs and how do they bring about their effects? How and why do drugs work in a dose-dependent manner? What happens to a drug after you swallow or inject it? These and related questions are addressed and the underlying pharmacological principles illustrated with a variety of theoretical and real-life examples. Prerequisites: CHEM 101 and BIOL 107. Limited to 2nd and 3rd year students.

PMCOL202 Topics in Pharmacology Course Page

Description: This course is an extension of PMCOL 201. Lectures will examine in more detail the basic pharmacology of autonomic, nervous cardiovascular, renal and gastrointestinal systems. Prerequisites: PMCOL 201. Corequisites: PHYSL 210, or PHYSL 212 and 214, or ZOOL 241 and 242.

PMCOL300 Introduction to Pharmacology Course Page

Description: Lectures are used to illustrate the principles of pharmacology including rational application of commonly used drugs to the treatment of disease. This course is available only to students registered in the Dental Hygiene Diploma program.

PMCOL301 Introduction to Research in Pharmacology Course Page

Description: This is a course designed to introduce students to pharmacological research. The students will participate in active research programs being run in the Department of Pharmacology. Restricted to Pharmacology Honors or Specialization students in the third year of their program. There will be a limited number of spaces available.

PMCOL302 Introduction to Research in Pharmacology Course Page

Description: This is a course designed to introduce students to pharmacological research. The students will participate in active research programs being run in the Department of Pharmacology. Restricted to Pharmacology Honors or Specialization students in the third year of their program. There will be a limited number of spaces available.

PMCOL303 Introduction to Toxicology Course Page

Description: The adverse effects of xenobiotics on biological systems are discussed. Principles of toxicology are introduced. Responses of target organs to selected toxicants are described, with emphasis on molecular mechanisms. Special topics include chemical carcinogenesis, nanotoxicology, and endocrine disruptors. Prerequisites: PMCOL 201 and 202, BIOCH 200, PHYSL 210, or 212 and 214, or consent of Department.

PMCOL305 An Introduction to the Pharmacology of Drug Abuse Course Page

Description: An introduction to the complexities of drug abuse and the drugs of abuse. The student will be introduced to the psychological and social problems of drug abuse and their impact upon the abuser. Objectives of the course are to develop an understanding of addiction and a detailed knowledge of the nature of the commonly abused substances. Emphasis will be placed upon the pharmacology of drugs of abuse. Prerequisites: one of the following BIOCH 200, BIOL 201, CELL 201, PHYSL 210, PHSYL 212 and 214, PMCOL 201, PSYCO 275, ZOOL 241 and 242.

PMCOL337 Experimental Procedures in Pharmacology Course Page

Description: Provides a hands-on experience in addressing basic pharmacological questions. The course will employ both in vitro techniques and behavioural models. Emphasis will be placed on experimental design and data collection, analysis and presentation. Normally restricted to third year Pharmacology Specialization or Honors students. Students not in these programs may be admitted via consent of the instructor if space is available.

PMCOL343 Scientific Basis of Pharmacology: Part I Course Page

Description: This course, together with the subsequent PMCOL 344, provides a comprehensive study of the modern science of pharmacology. The objective of the course is to study how drugs act on physiological systems. The areas covered will include neuropharmacology and neuroendocrine pharmacology. This course may be especially useful to those students who wish to pursue a career in health sciences. Prerequisite: PMCOL 201 or PMCOL 202 or equivalent. Pre or corequisite: BIOCH 200 and PHYSL 210, or 212 and 214, or consent of instructor. In the case of over subscription, preference will be given to students in the Pharmacology Specialization or Honors Programs.

PMCOL344 Scientific Basis of Pharmacology: Part II Course Page

Description: A continuation of PMCOL 343 with an emphasis on gastrointestinal pharmacology, chemotherapy of malignant and infectious diseases and pharmacological intervention in metabolic diseases. Prerequisite: PMCOL 343 or consent of instructor. In the case of over subscription, preference will be given to students in the Pharmacology Specialization or Honors Programs.

PMCOL371 Cellular Neuroscience Course Page

Description: Lectures presented by the Faculty of Medicine and Dentistry and the Faculty of Science on nerve cell membranes, ion channels, neurotransmitters and their receptors, synaptic mechanisms and plasticity, gene regulation and development, the physiology of small neural networks and disorders involving basic mechanisms. Prerequisite: PHYSL 210, or 212 and 214, or 252, or ZOOL 242. Students who have taken ZOOL 342 may not receive credit in PMCOL 371.

PMCOL401 Pharmacology Tutorial Course Page

Description: Independent research course. "Hands-on" experience is seen as a valuable asset for students graduating from BSc programs. With this in mind, this course provides an opportunity to work with a Faculty member on a research project during the Fall semester. The student and supervisor will mutually agree upon the details of the project. This is an excellent opportunity to learn current laboratory techniques, data analysis, laboratory notebook maintenance and presentation skills. Literature-based projects may also be available in which the student will be required to identify a research question and meet with the supervisor at regular intervals for discussion and guidance on preparation of a term paper and poster presentation. Prerequisites: PMCOL 343 and 344. Available only to students in the Pharmacology Specialization program or students who are granted consent by the Department of Pharmacology.

PMCOL402 Pharmacology Tutorial Course Page

Description: Independent research course. "Hands-on" experience is seen as a valuable asset for students graduating from BSc programs . With this in mind, this course provides an opportunity to work with a Faculty member on a research project during the Winter semester. The student and supervisor will mutually agree upon the details of the project. This is an excellent opportunity to learn current laboratory techniques, data analysis, laboratory notebook maintenance and presentation skills. Literature-based projects may also be available in which the student will be required to identify a research question and meet with the supervisor at regular intervals for discussion and guidance on preparation of a term paper and poster presentation. Prerequisites: PMCOL 343 and 344. Available only to students in the Pharmacology Specialization program or students who are granted consent by the Department of Pharmacology.

PMCOL412 Drugs and the Nervous System Course Page

Description: The goal of PMCOL 412 is to learn about the molecular basis of disorders of the nervous system, current therapies in use, as well as novel potential treatments that are in clinical trials or at the preclinical experimental stage. Research frontiers in pain and neurodegenerative disorders such as Alzheimer, Parkinson and Huntington's disease, amyotrophic lateral sclerosis and multiple sclerosis among others, will be explored. Novel therapeutic targets and the potential treatments of tomorrow will be discussed. Prerequisites: PMCOL 343 and 344 or 371 or ZOOL 342 or consent of instructor.

PMCOL415 Cardiovascular Pharmacology Course Page

Description: Critical discussion and analysis of current research papers in cardiovascular pharmacology, grouped into themes. Recent developments and use of the literature will be emphasized. In-class participation during roundtable discussion to critique assigned papers is essential. Each theme will be accompanied by the student's written analyses of papers assigned but not discussed in class, in the format of a condensation/critique. Prerequisites: PMCOL 343 and 344. In cases of limited space, preference will be given to students in the Pharmacology program.

PMCOL416 Current Topics in Endocrine Pharmacology Course Page

Description: This course examines in detail, drugs (including natural hormones) that are used for treatment of endocrine diseases (e.g. diabetes, infertility, and growth deficiency). The focus of the course is the action of drugs on hormone receptors and on the regulation of hormone synthesis and secretion. Prerequisite: PMCOL 343 or 344 or consent of instructor.

PMCOL425 Problem Solving in Pharmacology and Therapeutics Course Page

Description: Students will be presented with problem cases involving patients with conditions, possibly needing drug therapy. They will identify the issues needing resolution, work collectively to find information to resolve them, and present these and their application to each patient to the group. The group will work to resolve outstanding issues after the presentations. Intended for senior undergraduate students. Prerequisites: PMCOL 343 and 344 and consent of Instructor.

PMCOL450 Diabetes and Its Pharmacotherapy Course Page

Description: This course will provide an overview of the current understanding of blood glucose homeostasis, insulin secretion and action, the actions of other important blood sugar-regulating hormones and the pathology of diabetes. Current pharmacological approaches for lowering blood glucose will be discussed, as will the latest experimental approaches in identifying potential drug targets and new treatments for diabetes. At the end of the course, students should have an appreciation for the mechanisms that control glucose homeostasis in health and diabetes, the diversity of drug targets and mechanisms by which diabetes drugs promote glucose control, and current rationale and lines of research leading to potential new treatments. Prerequisites: PMCOL 343 and 344 or consent of instructor.

PMCOL475 Signal Transduction Systems as Pharmacological Targets Course Page

Description: Regulation of various aspects of cell regulation, including proliferation, differentiation, metabolism, survival, motility, and gene transcription, occur mainly via protein phosphorylation in a complex array of well-organized signal transduction pathways. This course will cover topics related to the pharmacological investigation of cellular transduction systems, the discovery of small molecules that alter cell signaling, and how pharmacological manipulation of these signaling pathways may be useful in the drug treatment of a diverse range of diseases, including metastatic, cardiovascular, inflammatory, immune, metabolic and neurodegenerative diseases. Prerequisites: PMCOL 343 and 344.

PMCOL498A Pharmacology Research Program Course Page

Description: During their fourth year all Honors candidates are required to carry out a program of directed research under the supervision of a staff member. This program will be related to the special interest of the student and will involve experimental work as well as two presentations and a written report on the part of the student. Students are encouraged to make arrangements with a supervisor of their choice before the fall term begins. Prerequisite: consent of Department. Normally available to fourth-year Honors students only.

PMCOL498B Pharmacology Research Program Course Page

Description: During their fourth year all Honors candidates are required to carry out a program of directed research under the supervision of a staff member. This program will be related to the special interest of the student and will involve experimental work as well as two presentations and a written report on the part of the student. Students are encouraged to make arrangements with a supervisor of their choice before the fall term begins. Prerequisite: consent of Department. Normally available to fourth-year Honors students only.

PMCOL501 Pharmacology Tutorial, Research, and Reading Course Course Page

Description: This course is similar to PMCOL 401 except that the course material and student performance will be at a level suitable for graduate students.

PMCOL502 Pharmacology Tutorial, Research, and Reading Course Course Page

Description: This course is similar to PMCOL 401 except that the course material and student performance will be at a level suitable for graduate students.

PMCOL508 Molecular Pharmacology Course Page

Description: This course aims to provide an understanding of the general mechanisms of drug action at the molecular level. Theoretical aspects of drug-receptor interaction are presented in detail followed by a consideration of the mechanisms of signal transduction that have been associated with different receptor types. Prerequisite: consent of Department.

PMCOL510 Advanced Topics Course Page
No description available for this course.
PMCOL511 Advanced Topics Course Page
No description available for this course.
PMCOL512 Pharmacology of the Synapse Course Page

Description: Current concepts of neurotransmitters, neuromodulators and trophic factors are discussed in the context of the normal, diseased and developing nervous systems. Students should have some biological background either in physiology, pharmacology, zoology, or the neurosciences. Prerequisite: consent of Department.

PMCOL514 Biophysical Aspects of Ion Channel Pharmacology Course Page

Description: A comprehensive examination of ion channels and their pharmacology. Topics to be covered include: molecular pharmacology, fundamental principles of bioelectricity, ion channel recording, analysis, classification, molecular biology, structure, pathophysiology and hereditary disease. Prerequisite: consent of the Department

PMCOL515 Advanced Topics in Cardiovascular Pharmacology Course Page

Description: Critical discussion and analysis of current research papers in cardiovascular pharmacology, grouped into themes. Recent developments and use of the literature will be emphasized. In-class participation during round table discussion to critique assigned papers is essential. Each theme will be accompanied by the student's written analyses of papers assigned but not discussed in class, in the format of a condensation/critique. Prerequisite: consent of the Department.

PMCOL525 Problem Solving in Pharmacology and Therapeutics Course Page

Description: Students will be presented with problem cases involving patients with conditions, possibly needing drug therapy. They will identify the issues needing resolution, work collectively to find information to resolve them, and present these and their application to each patient to the group. The group will work to resolve outstanding issues after the presentations. Intended for graduate students. Prerequisites: PMCOL 343 and 344 and consent of Instructor.

PMCOL550 Introduction to the Pharmacology of Diabetes Course Page

Description: This course is intended for graduate students and will provide an overview of the current understanding of blood glucose homeostasis, insulin secretion and action, the actions of other important blood sugar-regulating hormones and the pathology of diabetes. Current pharmacological approaches for lowering blood glucose will be discussed, as will the latest experimental approaches in identifying potential drug targets and new treatments for diabetes. At the end of the course, students should have an appreciation for the mechanisms that control glucose homeostasis in health and diabetes, the diversity of drug targets and mechanisms by which diabetes drugs promote glucose control, and current rationale and lines of research leading to potential new treatments. Prerequisites: PMCOL 343 and 344 or consent of Department.

PMCOL575 Signal Transduction Systems as Pharmacological Targets Course Page

Description: Regulation of various aspects of cell regulation, including proliferation, differentiation, metabolism, survival, motility, and gene transcription, occur mainly via protein phosphorylation in a complex array of well-organized signal transduction pathways. This course will cover topics related to the pharmacological investigation of cellular transduction systems, the discovery of small molecules that alter cell signaling, and how pharmacological manipulation of these signaling pathways may be useful in the drug treatment of a diverse range of diseases, including metastatic, cardiovascular, inflammatory, immune, metabolic and neurodegenerative diseases. Prerequisites: Consent of Department.

PMCOL612 Drugs and the Nervous System Course Page

Description: Pharmacological management of disease in the central nervous system is presented in the context of current knowledge of neuroscience and neurochemistry. Prerequisites: consent of the Department.