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Oncology

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ONCOL233 Concepts and Applications in Medical Physics Course Page

Description: Introduction into fundamental medical physics concepts including theory of atomic and nuclear structure, radioactivity, and electromagnetic and particulate radiation. Topics to be covered include production of medically useful radiation, interaction of radiation with matter, radiation dose, and an introduction to physics concepts used in a radiation oncology environment. Prerequisites: PHYS 124, 126, and MATH 113 or 114, or permission of the department.

ONCOL234 Therapeutic and Imaging Equipment in Radiation Therapy Course Page

Description: Builds on the concepts covered in ONCOL 233, with a shifting emphasis towards production of radiation, its shaping and measurements in the clinical environment as well as introduction to the fundamental concepts in equipment used in radiation therapy. Specific topics include: general principles of X-ray tube, Linac, Cobalt machine, dosimetry instrumentation, principles of diagnostic imaging techniques (including X-ray imaging, CT, MRI, PET and SPECT), innovative radiation treatment methods, treatment simulators; imaging equipment used for radiation therapy verification and general QA procedures for all imaging techniques as well as brachytherapy equipment. Prerequisite: ONCOL 233.

ONCOL243 Radiation Protection and Safety Course Page

Description: Introduction of the fundamental concepts in radiation protection and safety for the patient, self, and general public. Topics include: general principles and practices of working with radiation in a healthcare environment, differences in protection required for different types of radiation, basic radiation shielding considerations and facility design, monitoring and measurement of radiation for protection purposes, and relevant regulatory agencies and associated standards. Prerequisite: Permission of the department.

ONCOL253 Cancer Biology Course Page

Description: An introduction to the biology of cancer highlighting features that distinguish normal cells from cancer cells. Specific topics include the genetic basis of cancer, control of cell proliferation, invasion and metastasis, mechanism of action of cancer drugs and the development of resistance. Prerequisite: CELL 201.

ONCOL254 Principles of Oncology Course Page

Description: A survey course outlining the basic concepts in clinical oncology including epidemiology, cancer screening, cancer staging and pathology, molecular diagnostics, all modalities of treating primary, metastatic and resistant cancers. Definitions for the application of medical terminology will also be addressed. Prerequisite: Permission of the Department.

ONCOL255 Introduction to Oncology Course Page

Description: Principles and concepts of clinical oncology. Prerequisite: ONCOL 254.

ONCOL306 Imaging Principles/Pathology Course Page

Description: A unique course exploring the use of imaging in radiation therapy from a radiologic, radiation oncologic, and radiotherapeutic perspective. Students will gain skills in operating imaging software, identifying normal relational and cross sectional anatomy and pathological conditions using a variety of imaging modalities, and radiographic images, contouring tumor volumes, and will be expected to analyze and critique treatment images to make informed treatment decisions. Prerequisite: ANAT 305 or permission of the department.

ONCOL309 Clinical Oncology I Course Page

Description: The field of radiation oncology is introduced, as well as the evaluation and treatment of tumours with ionizing radiation. Students will begin the study of the various modalities of radiation treatment, and the respective treatment regimens and techniques utilized for the most common tumour sites. Prerequisite: Permission of the Department and ONCOL 255.

ONCOL310 Clinical Oncology II Course Page

Description: The study of the field of radiation oncology is further developed. By the completion of the course, students will have developed an understanding of the various treatment options for each of the tumour sites, and the respective treatment regimes, techniques, schedules, results, and toxicities of treatment with ionizing radiation. Prerequisite: ONCOL 309.

ONCOL320 Introduction to Oncology Course Page

Description: Provides an introduction to oncology with an emphasis on the molecular and cellular biology of cancer. Specific topics include the genetic basis of cancer, the control of cell proliferation, metastasis, tumour immunology, angiogenesis, and cancer therapies. Prerequisite: BIOL 201 or CELL 201 with a minimum grade of C, or consent of the Department.

ONCOL335 Radiobiology Course Page

Description: An introduction to the physics, chemistry and biology of radiation effects on cells and tissues. Concepts discussed include the biological factors that influence the response of normal and neoplastic cells to radiation therapy; cell survival curves; linear energy transfer and relative biological effectiveness; effects on tissues of time, dose and fractionation of radiation treatment; and emerging concepts in radiobiology. Prerequisites: ONCOL 253 and 254.

ONCOL355 Treatment Planning and Dosimetry I Course Page

Description: The foundation of radiation therapy treatment planning with the principles of radiation dose deposition within the patient, characteristics of radiation beams, and the intricacies of treatment calculations applied in order to develop an appropriate treatment strategy for typical tumor locations. The course covers both low and high energy X-ray, electron and Cobalt60 dose calculations for a variety of treatment techniques. Prerequisite: ONCOL 233, 234.

ONCOL356 Treatment Planning and Dosimetry II Course Page

Description: Concepts from ONCOL 355 are explored in more detail. Advanced topics in treatment planning will be covered, including 4 dimensional treatment planning, Intensity Modulated Radiation Therapy, Inverse planning, Arc therapy, and Brachytherapy planning. Prerequisite: ONCOL 355.

ONCOL424 Nutrition and Metabolism Related to Cancer Course Page

Description: A lecture and reading course to address nutritional issues specifically related to cancer prevention, diagnosis, treatment and recovery. Graduate students may not register for credit (see ONCOL 524). Credit will only be given for one of ONCOL 524, 424 and AFNS 524, 424. Prerequisite: (NUTR 301 and 302) or (NU FS 352 and 6* Biochemistry) or ONCOL 320.

ONCOL425 Advanced Topics in Cancer Research Course Page

Description: This course spans both the fall and winter terms. At least four different modules will be offered in each term. Students can elect to take the course for 3 units credit (total of four modules over the course of the year) or 6 unit credits (total of eight modules over the course of the year). Each module is comprised of 6 sessions of 80 min each and will be taught independently by individual instructors. Modules will have both lecture and group discussion components. Additional modules will be added based on interest and demand. Prerequisite: CELL 201/BIOL 201 and a 300 level science course in BIOCH, GENET, ONCOL, CELL or consent of the Department.

ONCOL425A Advanced Topics in Cancer Research Course Page

Description: This course spans both the fall and winter terms. At least four different modules will be offered in each term. Students can elect to take the course for 3 units credit (total of four modules over the course of the year) or 6 unit credits (total of eight modules over the course of the year). Each module is comprised of 6 sessions of 80 min each and will be taught independently by individual instructors. Modules will have both lecture and group discussion components. Additional modules will be added based on interest and demand. Prerequisite: Cell 201/Biol 201 and a 300 level science course in Bioch, Genet, Oncol, Cell or consent of the Department.

ONCOL425B Advanced Topics in Cancer Research Course Page

Description: This course spans both the fall and winter terms. At least four different modules will be offered in each term. Students can elect to take the course for 3 units credit (total of four modules over the course of the year) or 6 unit credits (total of eight modules over the course of the year). Each module is comprised of 6 sessions of 80 min each and will be taught independently by individual instructors. Modules will have both lecture and group discussion components. Additional modules will be added based on interest and demand. Prerequisite: Cell 201/Biol 201 and a 300 level science course in Bioch, Genet, Oncol, Cell or consent of the Department.

ONCOL475 Fundamentals of Radiopharmaceutical Sciences Course Page

Description: Practical techniques in the use of radioisotopes in the life sciences. This course focuses on safe handling of radio-isotopes, measurement of radioactivity, performance of radiochemical reactions and the application of radionuclides in life sciences (99mTc-labeling and 18F-labeling). The accompanying seminar provides the necessary background knowledge to engage with the practical challenges of radionuclide handling. Credit cannot be obtained for both ONCOL 475 and 575. Prerequisite: Consent of the Department.

ONCOL520 Tumor Biology Course Page

Description: The course will provide an introduction to the basic science of oncology. Topics to be covered comprise: the genetic basis of cancer, including the role of proto-oncogenes and tumor suppressor genes; mechanisms of carcinogenesis and radiation-sensitivity, including DNA repair and cell cycle control; the molecular basis of tumor metastasis, including tumor cell invasion, extravasation and dormancy; the role of inflammation in cancer initiation and progression; angiogenesis; cancer genetics, and epigenetics; cell signaling; experimental therapeutics; cancer stem cells; drug-resistance; metabolism and palliation. Course offered in alternate (even-numbered) years. Prerequisites: BIOCH 200, and one of the following: BIOCH 320 or 330 or ONCOL 320.

ONCOL524 Nutrition and Metabolism Related to Cancer Course Page

Description: A lecture and reading course to address nutritional issues specifically related to cancer prevention, diagnosis, treatment and recovery. Lectures are the same as for ONCOL 424, but with additional assignments and evaluation appropriate to graduate studies. Credit will only be given for one of ONCOL 524, 424 and AFNS 524, 424. Prerequisite: (NUTR 301 and 302) or (NUFS 352 and 6* Biochemistry) or ONCOL 320.

ONCOL550 Medical Radiation Physics Course Page

Description: Fundamentals of radiation physics, production and properties of ionizing radiation and their interactions with matter and tissue. Interactions of photons and of charged particles with matter. Concepts of radiation dosimetry (theoretical and experimental, cavity theory and ionization chambers). Consent of Department required.

ONCOL552 Fundamentals of Applied Dosimetry Course Page

Description: Theory and practical techniques of external beam radiotherapy and brachytherapy. Topics include single and multiple external beams, scatter analysis, inhomogeneity corrections, intensity-modulated radiotherapy (IMRT), dose calculation algorithms, fundamentals of brachytherapy, and brachytherapy dosimetry systems. Prerequisite: ONCOL 550.

ONCOL554 Laboratory in Medical Radiation Physics Course Page

Description: Practical aspects of medical physics as applied to radiation therapy. Exposure to the operation of various therapy machines and dose measuring equipment. Application of techniques to measure physical parameters of radiation beams. Introduction to radiation treatment planning with techniques for specific tumor sites. Prerequisite: ONCOL 550. Corequisite: ONCOL 552.

ONCOL556 Laboratory in Imaging Course Page

Description: Provides clinical and practical experience with diagnostic imaging equipment, to adequately provide consultative support required of a clinical medical physicist in imaging. Perform calibration and quality assurance procedures on medical imaging modalities. Prerequisites: ONCOL 550 and 562. Corequisites: ONCOL 568 and 564.

ONCOL558 Health Physics Course Page

Description: Sources of radiation, basic dosimetry, and hazards of ionizing radiation. Basics of radiation safety. Techniques for the detection, use, and safe handling of radiation sources. Radiation safety codes, laws and regulations. Consent of Department required.

ONCOL560 Technology in Radiation Oncology Course Page

Description: Explore the use of technology and physics principles in the diagnosis, tumour and normal tissue delineation, treatment planning, treatment delivery, and treatment verification as applied to cancer patients. Consent of Department required.

ONCOL562 Theory of Medical Imaging Course Page

Description: A system theory approach to the production, analysis, processing and reconstruction of medical images. An extensive use of Fourier techniques is used to describe the processes involved with conventional radiographic detectors, digital and computed radiography. Review and application of image processing techniques used in diagnostic and therapeutic medicine. Consent of Department required.

ONCOL564 Physics of Nuclear Medicine Course Page

Description: Discussion of the fundamental physics of radioactivity, the use of unsealed sources in medical diagnosis and treatment. Unsealed source dosimetry, nuclear measurement instrumentation, spectrometry. Design and function of gamma cameras, single photon emission tomography, and positron emission tomography. Prerequisites: ONCOL 550 and 562.

ONCOL566 Radiation Biophysics Course Page

Description: Current theories and models of cellular responses to ionizing radiation. Modification of radiation response. Radiobiology of normal and neoplastic tissue systems. Late effects of radiation on normal tissue. Radiobiological modeling of normal tissue complication, probability and tumor control probability.

ONCOL568 Physics of Diagnostic Radiology Course Page

Description: Rigorous development of the physics of x-ray production, interaction and detection in diagnostic radiology, including mammography and ultrasound. In-depth analysis of analog and digital systems in radiography and fluoroscopy is given. The description and design of computed tomographic systems as well as the associated reconstruction algorithms from single to multislice helical systems are studied. Prerequisites: ONCOL 550, 562.

ONCOL570 Directed Reading in Experimental Oncology Course Page

Description: Reading and discussion of current research literature on selected topics in experimental oncology under the direction of one or more faculty members. Topics presently available include cell adhesion mechanisms, cell cycle regulation, DNA repair, radiotherapy and susceptibility and resistance, oncogenes/tumor suppressor genes, and tumor cell metastasis. Notes: (1) Grades will be based on participation in group discussions and/or written reports from assigned readings with emphasis on critical evaluation of the subject matter. (2) Students in other graduate programs may register with the consent of Instructors. Prerequisite: consent of Department.

ONCOL575 Fundamentals of Radiopharmaceutical Sciences Course Page

Description: Practical techniques in the use of radioisotopes in the life sciences. This course focuses on safe handling of radio-isotopes, measurement of radioactivity, performance of radiochemical reactions and the application of radionuclides in life sciences (99mTc-labeling and 18F-labeling). The accompanying seminar provides the necessary background knowledge to engage with the practical challenges of radionuclide handling. Credit cannot be obtained for both ONCOL 475 and 575. Prerequisite: Consent of the Department.

ONCOL580 Molecular Imaging: Tracers, Targets, Techniques Course Page

Description: This course will provide an overview of molecular imaging probes and their application in basic and clinical science. The course will have an emphasis on radionuclide based probes and on their application in oncology but will also introduce other classes of probes (optical, MR, x-ray contrast, ultrasound and photoacoustic) and other pathologies. The course will examine imaging techniques, cell and tissue targets for imaging probes, the chemical elaboration of molecular imaging probes and some applications in the diagnosis and treatment of human disease. Molecular imaging in drug development will also be addressed. Prerequisite: Consent of the Department.

ONCOL600A Graduate Medical Physics Seminar Course Page

Description: Weekly seminars given by faculty on topics of interest to the medical physics community that are not formally included with the other didactic courses. Includes medical statistics, anatomy/physiology for medical physics, site-specific cancer, experience in clinic, Monte Carlo simulation, Matlab, MR spectroscopy, finite element analysis, and image fusion. No prerequisite.

ONCOL600B Graduate Medical Physics Seminar Course Page

Description: Weekly seminars given by faculty on topics of interest to the medical physics community that are not formally included with the other didactic courses. Includes medical statistics, anatomy/physiology for medical physics, site-specific cancer, experience in clinic, Monte Carlo simulation, Matlab, MR spectroscopy, finite element analysis, and image fusion. No prerequisite.

ONCOL620 Recent Advances in Cancer Research Course Page

Description: A directed reading and seminar course based on recent developments in the cellular and molecular biology of cancer. The students will critically review papers selected from the recent literature and give oral presentations. Prerequisites: ONCOL 520 and consent of Department. Offered in alternate years.

ONCOL660 Current Topics in Cancer Research Course Page

Description: A general seminar/discussion course on recent advances in a wide range of topics related to cancer development and management. Selected topics include experimental therapeutics, molecular oncogenetics, tumour immunobiology, DNA repair, and cell cycle regulation. Notes: (1) all graduate students in the Department of Oncology are expected to attend the seminars whether or not they are registered in the course. (2) All graduate students in the Department of Oncology should register in the course in their second year and present a seminar based on their research project. (3) All graduate students registered in ONCOL 660 will write a paper on a selected topic. Restricted to graduate students in the Department of Oncology.

ONCOL661 Current Topics in Cancer Research II Course Page

Description: A general seminar course based on recent advances in a wide range of topics related to cancer. Note: Oncology 661 should be taken in the first term of the year in which Oncology 660 is taken. Graduate students must obtain one credit from ONCOL 661 in order to meet the minimum requirements for the MSc and PhD programs in the Department of Oncology. Restricted to graduate students in the Department of Oncology.

ONCOL690 Biomedical Magnetic Resonance Methods and Applications Course Page

Description: Advanced course on modern magnetic resonance techniques including in-depth description of hardware; advanced imaging sequences and image reconstruction methods; methodologies for in-vivo magnetic resonance spectroscopy. Prerequisite: BME 564 and consent of Instructor.

ONCOL691 Advanced Magnetic Resonance Physics Course Page

Description: Guided lecture course with preparation and delivery of teaching lectures on a current topic of Magnetic Resonance research in conjunction with ONCOL 692 and 693 presentations. Prerequisite: ONCOL 690 and consent of Instructor.

ONCOL692 Advanced Radiological and Nuclear Imaging Physics Course Page

Description: Guided reading course in advanced ultrasound, fluoroscopy, X-ray CT, or nuclear imaging with preparation and presentation of teaching lectures in conjunction with ONCOL 691 and 693 presentations. Prerequisite: ONCOL 562, 564, 568, 600, and consent of Instructor.

ONCOL693 Advanced Radiotherapeutic Physics Course Page

Description: Guided reading course with preparation and delivery of teaching lectures in novel radiotherapeutic techniques, advanced radiation techniques and delivery in conjunction with ONCOL 691 and 692 presentations. Prerequisite: ONCOL 550, 552, 600, and consent of Instructor.